Complex Evolution of 7E Olfactory Receptor Genes in Segmental Duplications
نویسندگان
چکیده
منابع مشابه
How segmental duplications shape our genome: recent evolution of ABCC6 and PKD1 Mendelian disease genes.
The completion of the Human Genome Project has brought the understanding that our genome contains an unexpectedly large proportion of segmental duplications. This poses the challenge of elucidating the consequences of recent duplications on physiology. We have conducted an in-depth study of a subset of segmental duplications on chromosome 16. We focused on PKD1 and ABCC6 duplications because mu...
متن کاملSerial segmental duplications during primate evolution result in complex human genome architecture.
The human genome is particularly rich in low-copy repeats (LCRs) or segmental duplications (5%-10%), and this characteristic likely distinguishes us from lower mammals such as rodents. How and why the complex human genome architecture consisting of multiple LCRs has evolved remains an open question. Using molecular and computational analyses of human and primate genomic regions, we analyzed the...
متن کاملEvolution of olfactory receptor genes in the human genome.
Olfactory receptor (OR) genes form the largest known multigene family in the human genome. To obtain some insight into their evolutionary history, we have identified the complete set of OR genes and their chromosomal locations from the latest human genome sequences. We detected 388 potentially functional genes that have intact ORFs and 414 apparent pseudogenes. The number and the fraction (48%)...
متن کاملRecent segmental duplications in the human genome.
Primate-specific segmental duplications are considered important in human disease and evolution. The inability to distinguish between allelic and duplication sequence overlap has hampered their characterization as well as assembly and annotation of our genome. We developed a method whereby each public sequence is analyzed at the clone level for overrepresentation within a whole-genome shotgun s...
متن کاملAnalysis of segmental duplications via duplication distance
MOTIVATION Segmental duplications are common in mammalian genomes, but their evolutionary origins remain mysterious. A major difficulty in analyzing segmental duplications is that many duplications are complex mosaics of fragments of numerous other segmental duplications. RESULTS We introduce a novel measure called duplication distance that describes the minimum number of duplications necessa...
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ژورنال
عنوان ژورنال: Genome Research
سال: 2003
ISSN: 1088-9051
DOI: 10.1101/gr.769003